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A Phase 1/2 Open-label, Biomarker-defined Cohort Trial to Evaluate the Safety, Determine the Recommended Combination Dosing, and Assess Early Antitumor Activity of Tipifarnib and Alpelisib for the Treatment of Adult Participants Who Have HRAS-overexpressing and/or PIK3CA-mutated and/or - Amplified Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

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Trial Profile

A Phase 1/2 Open-label, Biomarker-defined Cohort Trial to Evaluate the Safety, Determine the Recommended Combination Dosing, and Assess Early Antitumor Activity of Tipifarnib and Alpelisib for the Treatment of Adult Participants Who Have HRAS-overexpressing and/or PIK3CA-mutated and/or - Amplified Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 17 Nov 2025

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At a glance

  • Drugs Alpelisib (Primary) ; Tipifarnib (Primary)
  • Indications Head and neck cancer; Squamous cell cancer
  • Focus Adverse reactions; Biomarker
  • Acronyms KURRENT; KURRENT-HN
  • Sponsors Kura Oncology

Most Recent Events

  • 18 Oct 2025 Results presented in the Kura oncology media release.
  • 03 Sep 2025 According to Kura Oncology media release, phase 1 results from this study will be presented as a poster on October 20, 2025 at the 2025 European Society for Medical Oncology (ESMO) Congress.
  • 15 Aug 2025 Planned End Date changed from 1 Jul 2025 to 1 Dec 2025.

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