Trial Profile

A Phase 1/2 Open-label, Biomarker-defined Cohort Trial to Evaluate the Safety, Determine the Recommended Combination Dosing, and Assess Early Antitumor Activity of Tipifarnib and Alpelisib for the Treatment of Adult Participants Who Have HRAS-overexpressing and/or PIK3CA-mutated and/or - Amplified Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

Status: Active, no longer recruiting

Phase of Trial: Phase I/II

Latest Information Update: 05 Sep 2025

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At a glance

15 Aug 2025 Planned End Date changed from 1 Jul 2025 to 1 Dec 2025.
15 Aug 2025 Planned primary completion date changed from 1 Jul 2025 to 1 Dec 2025.
01 May 2025 According to a Kura Oncology media release, company to present data from this study in the second half of 2025.

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