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A Phase I, Open-label, Non-randomised Study to Assess the Effect of Itraconazole (a CYP3A4 Inhibitor), Rifampicin (a CYP3A4 Inducer), and Omeprazole (a Proton Pump Inhibitor) on the Pharmacokinetics of a Single Oral Dose of Adavosertib in Patients With Advanced Solid Tumours

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Trial Profile

A Phase I, Open-label, Non-randomised Study to Assess the Effect of Itraconazole (a CYP3A4 Inhibitor), Rifampicin (a CYP3A4 Inducer), and Omeprazole (a Proton Pump Inhibitor) on the Pharmacokinetics of a Single Oral Dose of Adavosertib in Patients With Advanced Solid Tumours

Status: Discontinued
Phase of Trial: Phase I

Latest Information Update: 19 Sep 2022

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At a glance

  • Drugs Adavosertib (Primary) ; Itraconazole (Primary) ; Omeprazole (Primary) ; Rifampicin (Primary)
  • Indications Solid tumours
  • Focus Pharmacokinetics
  • Sponsors AstraZeneca

    • Most Recent Events

    • 31 Aug 2022 Status changed from recruiting to discontinued because the clinical development programme for Adavosertib has been discontinued.
    • 22 Mar 2022 Planned End Date changed from 23 Nov 2022 to 9 Nov 2022.
    • 22 Mar 2022 Planned primary completion date changed from 23 Nov 2022 to 9 Nov 2022.

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