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A Phase 2 Single-Arm Study of Amivantamab (JNJ-61186372) and Lazertinib in Metastatic EGFR-mutant Lung Cancer With Progressive or New CNS Metastases on Previous Treatment

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Trial Profile

A Phase 2 Single-Arm Study of Amivantamab (JNJ-61186372) and Lazertinib in Metastatic EGFR-mutant Lung Cancer With Progressive or New CNS Metastases on Previous Treatment

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 10 Jul 2024

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At a glance

  • Drugs Amivantamab (Primary) ; Lazertinib (Primary)
  • Indications Brain metastases; Non-small cell lung cancer
  • Focus Therapeutic Use

    • Most Recent Events

    • 04 Jun 2024 Status changed from active, no longer recruiting to completed, according to results presented at the 60th Annual Meeting of the American Society of Clinical Oncology.
    • 04 Jun 2024 Results (n=42) assessing the safety and efficacy of amivantamab plus lazertinib in patients with EGFR-mutant lung cancer and active central nervous system disease, presented at the 60th Annual Meeting of the American Society of Clinical Oncology.
    • 19 Dec 2023 Planned End Date changed from 1 Jul 2024 to 1 Jul 2025.

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