Trial Profile

Phase I, single-centre, open-label, seven-part, three-sequence, randomised crossover trial investigating the drug-drug interactions between six oral azole antifungals and a microdosed FXaI cocktail containing 25 µg rivaroxaban, 25 µg apixaban, and 50 µg edoxaban

Status: Completed

Phase of Trial: Phase I

Latest Information Update: 27 Jul 2021

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At a glance

Drugs Apixaban (Primary) ; Edoxaban (Primary) ; Rivaroxaban (Primary) ; Esomeprazole; Fluconazole; Isavuconazole; Itraconazole; Ketoconazole; Midazolam; Posaconazole; Voriconazole; Yohimbine
Indications Cardiovascular disorders; Embolism; Hypertension; Thromboembolism; Thrombosis
Focus Pharmacokinetics

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