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A Phase 1b/2 Dose-Escalation and Cohort-Expansion Study to Determine the Safety and Efficacy of BGB-11417as Monotherapy, in Combination With Dexamethasone and Carfilzomib/Dexamethasone in Patients With Relapsed/Refractory Multiple Myeloma and t(11;14)

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Trial Profile

A Phase 1b/2 Dose-Escalation and Cohort-Expansion Study to Determine the Safety and Efficacy of BGB-11417as Monotherapy, in Combination With Dexamethasone and Carfilzomib/Dexamethasone in Patients With Relapsed/Refractory Multiple Myeloma and t(11;14)

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 21 Aug 2024

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At a glance

  • Drugs Carfilzomib (Primary) ; Dexamethasone (Primary) ; Sonrotoclax (Primary)
  • Indications Multiple myeloma
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors BeiGene
  • Most Recent Events

    • 07 Aug 2024 According to BeiGene media release, the company has presented the results of Phase 1 trials demonstrating encouraging response rates, durable responses and manageable safety profiles in combination with dexamethasone in R/R multiple myeloma harboring translocation, at EHA 2024.
    • 12 Dec 2023 Results assessing the overall safety/tolerability profile as well as determine the MTD / MAD and establish the phase2 RP2D of sonrotoclax as monotherapy, in combination with dexamethasone, or in combination with dexamethasone plus carfilzomib in patients with R/R MM, presented at the 65th American Society of Hematology Annual Meeting and Exposition.
    • 13 Dec 2022 Preliminary safety results (at data cutoff: 1 July 2022; n=10) presented at the 64th American Society of Hematology Annual Meeting and Exposition.

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