A Phase 1b/2 Dose-Escalation and Cohort-Expansion Study to Determine the Safety and Efficacy of BGB-11417as Monotherapy, in Combination With Dexamethasone and Carfilzomib/Dexamethasone in Patients With Relapsed/Refractory Multiple Myeloma and t(11;14)
Latest Information Update: 26 Jul 2024
At a glance
- Drugs Carfilzomib (Primary) ; Dexamethasone (Primary) ; Sonrotoclax (Primary)
- Indications Multiple myeloma
- Focus Adverse reactions; Therapeutic Use
- Sponsors BeiGene
- 12 Dec 2023 Results assessing the overall safety/tolerability profile as well as determine the MTD / MAD and establish the phase2 RP2D of sonrotoclax as monotherapy, in combination with dexamethasone, or in combination with dexamethasone plus carfilzomib in patients with R/R MM, presented at the 65th American Society of Hematology Annual Meeting and Exposition.
- 13 Dec 2022 Preliminary safety results (at data cutoff: 1 July 2022; n=10) presented at the 64th American Society of Hematology Annual Meeting and Exposition.
- 01 Nov 2022 Planned End Date changed from 1 Sep 2025 to 1 Nov 2026.