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A Phase III, Multicentre, Randomised, Double-Blind Study to Assess the Safety and Efficacy of Emactuzumab vs. Placebo in Subjects With Tenosynovial Giant Cell Tumour

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Trial Profile

A Phase III, Multicentre, Randomised, Double-Blind Study to Assess the Safety and Efficacy of Emactuzumab vs. Placebo in Subjects With Tenosynovial Giant Cell Tumour

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 21 May 2024

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At a glance

  • Drugs Emactuzumab (Primary)
  • Indications Giant cell tumour of tendon sheath
  • Focus Registrational; Therapeutic Use
  • Acronyms TANGENT
  • Sponsors SynOx Therapeutics

    • Most Recent Events

    • 16 May 2024 Status changed from not yet recruiting to recruiting.
    • 30 Apr 2024 According to a SynOx Therapeutics media release, the loan facility provides SynOx with flexibility to fund additional clinical work in TGCT to augment TANGENT, activities to support the successful registration and commercialisation of emactuzumab in TGCT, and potentially to explore the use of emactuzumab in other CSF-1 driven and macrophage-mediated diseases.
    • 30 Apr 2024 According to a SynOx Therapeutics media release, company announces it has entered into a $35m loan facility with Hercules Capital, Inc. (NYSE: HTGC) (Hercules). The transaction strengthens the Companys balance sheet as it executes TANGENT, a registrational Phase 3 study of emactuzumab, SynOxs potentially best-in-class CSF-1(R) inhibiting monoclonal antibody (mAb) for the treatment of TGCT.

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