Trial Profile

A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel Study to Assess the Efficacy, Safety, Tolerability, PK, and Biomarker Effects of PTC857 in Adult Subjects With Amyotrophic Lateral Sclerosis (CARDINALS)

Status: Discontinued

Phase of Trial: Phase II

Latest Information Update: 01 Apr 2025

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At a glance

26 Mar 2025 Status changed from recruiting to discontinued.
26 Nov 2024 Results published in the PTC Therapeutics media release
26 Nov 2024 According to a PTC Therapeutics media release, Primary endpoint (Participant Ranks Based on the Combined Assessment of ALS Functional Rating Scale-Revised (ALSFRS-R) and Survival After 24 Weeks of Treatment (Intention-to-Treat [ITT] 1 Analysis Population)) has not been met.

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