Trial Profile

A Phase 2a, randomized, placebo-controlled, dose-ranging study to evaluate the safety and efficacy of PTC518 in subjects with Huntington's disease

Status: Completed

Phase of Trial: Phase II

Latest Information Update: 19 Jan 2026

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At a glance

Drugs Votoplam (Primary)
Indications Huntington's disease
Focus Adverse reactions; Therapeutic Use
Acronyms PIVOT-HD
Sponsors PTC Therapeutics

Most Recent Events

13 Jan 2026 Status changed from active, no longer recruiting to completed.
12 Jan 2026 According to a PTC Therapeutics media release, end-of-Phase 2 meeting with FDA held in Q4 2025 to discuss the votoplam Huntington's disease (HD) program
06 May 2025 According to a PTC Therapeutics media release, company plans to complete additional analyses and discuss next development and regulatory steps, including potential for accelerated approval

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