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Orismilast for the treatment of mild to severe hidradenitis suppurativa; A phase 2, open-label, proof of concept trial comparing the response to an oral tablet formulation of orismilast in adult patients with mild, moderate, and severe hidradenitis suppurativa; A single-centre, prospective, single arm, investigator-initiated clinical trial with 16 weeks twice times daily oral treatment

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Orismilast for the treatment of mild to severe hidradenitis suppurativa; A phase 2, open-label, proof of concept trial comparing the response to an oral tablet formulation of orismilast in adult patients with mild, moderate, and severe hidradenitis suppurativa; A single-centre, prospective, single arm, investigator-initiated clinical trial with 16 weeks twice times daily oral treatment

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 13 May 2024

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At a glance

  • Drugs Orismilast (Primary)
  • Indications Hidradenitis suppurativa
  • Focus Proof of concept; Therapeutic Use
  • Acronyms OSIRIS

    • Most Recent Events

    • 09 May 2024 Status changed from recruiting to completed as per results published in the Journal of the European Academy of Dermatology and Venereology.
    • 01 May 2024 Results examining tolerability, safety and efficacy of oral phosphodiesterase-4 (PDE4) inhibitior orismilast 10-40 mg twice daily (BID) in HS published in the Journal of the European Academy of Dermatology and Venereology
    • 15 Mar 2024 According to an UNION Therapeutics media release, data from the study were presented in the Journal of the European Academy of Dermatology and Venereology.

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