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A Phase 1, Open-label, Dose Escalation and Dose Expansion Study, to Investigate the Safety, Tolerability, and Pharmacokinetic Profile of AB521 Monotherapy and Combination Therapies in Participants With Clear Cell Renal Cell Carcinoma and Other Solid Tumors

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Trial Profile

A Phase 1, Open-label, Dose Escalation and Dose Expansion Study, to Investigate the Safety, Tolerability, and Pharmacokinetic Profile of AB521 Monotherapy and Combination Therapies in Participants With Clear Cell Renal Cell Carcinoma and Other Solid Tumors

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 30 Sep 2025

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At a glance

  • Drugs Cabozantinib (Primary) ; Casdatifan (Primary) ; Volrustomig (Primary) ; Zimberelimab (Primary)
  • Indications Renal cell carcinoma; Solid tumours
  • Focus Adverse reactions
  • Acronyms ARC-20; eVOLVE
  • Sponsors Arcus Biosciences

Most Recent Events

  • 06 Aug 2025 According to an Arcus Biosciences Media Release, more mature data from the ARC-20 cohorts evaluating casdatifan monotherapy in patients who had progressed on both an anti-PD-1 and a TKI anticipated in 2025. More mature data from the casdatifan plus cabozantinib cohort and initial data from the new ARC-20 cohorts evaluating casdatifan in the 1L and IO-experienced settings anticipated in 2026.
  • 01 Jun 2025 Results presented in an Arcus Biosciences Media Release.
  • 01 Jun 2025 According to an Arcus Biosciences media release, data from this study presented at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting.

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