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A Phase 1, Open-label, Dose Escalation and Dose Expansion Study, to Investigate the Safety, Tolerability, and Pharmacokinetic Profile of AB521 Monotherapy and Combination Therapies in Participants With Clear Cell Renal Cell Carcinoma and Other Solid Tumors

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Trial Profile

A Phase 1, Open-label, Dose Escalation and Dose Expansion Study, to Investigate the Safety, Tolerability, and Pharmacokinetic Profile of AB521 Monotherapy and Combination Therapies in Participants With Clear Cell Renal Cell Carcinoma and Other Solid Tumors

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 28 Nov 2025

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At a glance

  • Drugs Cabozantinib (Primary) ; Casdatifan (Primary) ; Volrustomig (Primary) ; Zimberelimab (Primary)
  • Indications Renal cell carcinoma; Solid tumours
  • Focus Adverse reactions
  • Acronyms ARC-20; eVOLVE
  • Sponsors Arcus Biosciences

Most Recent Events

  • 28 Oct 2025 According to an Arcus Biosciences Media Release, multiple readouts from the ARC-20 study of casdatifan are expected in 2026, including additional analyses of the late-line monotherapy cohorts early in 2026, followed by more mature data from the casdatifan plus cabozantinib cohort in mid-2026 and initial data from the early-line cohorts in the second half of 2026
  • 06 Oct 2025 According to an Arcus Biosciences Media Release, the Company will share more detail on these data and preview the expansion of its research efforts into autoimmune and inflammatory diseases.
  • 06 Oct 2025 Results published in the Media Release

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