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A Phase 1 Open-Label Dose Escalation and Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of LP-168 in Adult Patients With Relapse or Refractory B-Cell Lymphoma

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Trial Profile

A Phase 1 Open-Label Dose Escalation and Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of LP-168 in Adult Patients With Relapse or Refractory B-Cell Lymphoma

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 18 Jan 2024

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At a glance

  • Drugs Rocbrutinib (Primary)
  • Indications Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Follicular lymphoma; Mantle-cell lymphoma; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma; Waldenstrom's macroglobulinaemia
  • Focus Adverse reactions; First in man
  • Sponsors Guangzhou Lupeng Pharmaceutical

    • Most Recent Events

    • 12 Dec 2023 Results (n=168) reporting efficacy and safety data from phase 1 portion of this trial presented at the 65th American Society of Hematology Annual Meeting and Exposition
    • 12 Dec 2023 Results (N=33) assessing safety and preliminary efficacy data of LP-168 monotherapy in the R/R MCL patients presented at the 65th American Society of Hematology Annual Meeting and Exposition
    • 26 Sep 2023 Planned End Date changed from 31 Dec 2023 to 30 Jun 2024.
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