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An Open-label, Phase 1b, Dose Escalation and Expansion Study to Evaluate the Safety, Tolerability, Maximum Tolerated or Administered Dose, Pharmacokinetics, Pharmacodynamics and Efficacy of the Aryl Hydrocarbon Receptor Inhibitor (AhRi) BAY 2416964 in Combination With Pembrolizumab in Participants With Advanced Solid Tumors

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Trial Profile

An Open-label, Phase 1b, Dose Escalation and Expansion Study to Evaluate the Safety, Tolerability, Maximum Tolerated or Administered Dose, Pharmacokinetics, Pharmacodynamics and Efficacy of the Aryl Hydrocarbon Receptor Inhibitor (AhRi) BAY 2416964 in Combination With Pembrolizumab in Participants With Advanced Solid Tumors

Status: Discontinued
Phase of Trial: Phase I

Latest Information Update: 02 Mar 2025

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At a glance

  • Drugs BAY 2416964 (Primary) ; Pembrolizumab (Primary)
  • Indications Carcinoma; Head and neck cancer; Hypopharyngeal cancer; Laryngeal cancer; Mouth neoplasm; Non-small cell lung cancer; Oropharyngeal cancer; Solid tumours; Squamous cell cancer; Urogenital cancer
  • Focus Adverse reactions
  • Sponsors Bayer

Most Recent Events

  • 10 Feb 2025 Status changed from active, no longer recruiting to discontinued, because the last patient ended the study on 20th January 2025. Hence, the study ended as per the protocol.
  • 05 Nov 2024 Planned End Date changed from 14 Mar 2025 to 1 Dec 2025.
  • 14 Mar 2024 Planned End Date changed from 30 Dec 2025 to 14 Mar 2025.

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