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Phase I/II, Open-label, Dose Escalation and Dose Expansion Study to Evaluate Safety, Pharmacokinetics, Pharmacodynamics and Efficacy of AZD2936 Anti-TIGIT/Anti-PD-1 Bispecific Antibody in Participants With Advanced or Metastatic NSCLC

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Trial Profile

Phase I/II, Open-label, Dose Escalation and Dose Expansion Study to Evaluate Safety, Pharmacokinetics, Pharmacodynamics and Efficacy of AZD2936 Anti-TIGIT/Anti-PD-1 Bispecific Antibody in Participants With Advanced or Metastatic NSCLC

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 28 Sep 2024

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At a glance

  • Drugs Rilvegostomig (Primary)
  • Indications Adenocarcinoma; Non-small cell lung cancer; Squamous cell cancer
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Acronyms ARTEMIDE-01
  • Sponsors AstraZeneca; AstraZeneca AB

    • Most Recent Events

    • 03 Sep 2024 According to an AstraZeneca media release, two late-breaking oral presentations at WCLC will highlight efficacy and safety results from the ARTEMIDE-01 Phase I trial of rilvegostomig in patients with metastatic NSCLC, as well as from a Phase Ib/II trial of volrustomig (PD-1/CTLA-4) in combination with chemotherapy in the 1st-line for patients with advanced NSCLC.
    • 06 Aug 2024 According to a Compugen Ltd. media release, data from this trial is expected in second half of 2024.
    • 01 Aug 2024 Planned End Date changed from 27 Nov 2025 to 20 Apr 2026.

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