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A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PB2452 (Bentracimab) With and Without Ticagrelor Pretreatment in Chinese Healthy Volunteers

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Trial Profile

A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PB2452 (Bentracimab) With and Without Ticagrelor Pretreatment in Chinese Healthy Volunteers

Status: Discontinued
Phase of Trial: Phase I

Latest Information Update: 25 Jan 2024

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At a glance

  • Drugs Bentracimab (Primary) ; Ticagrelor
  • Indications Haemorrhage
  • Focus Adverse reactions; Pharmacodynamics
  • Sponsors PhaseBio Pharmaceuticals
  • Most Recent Events

    • 19 Jan 2024 Status changed from recruiting to discontinued. The study was initially stopped because of Covid-19. Later, it was found that the PK data for the dose of 18000 mg (which was going to be tested in Cohort-5), would be available from the ongoing Phase 3 study of this drug. Hence, the study was terminated.
    • 22 Dec 2021 Status changed from not yet recruiting to recruiting.
    • 19 Aug 2021 New trial record

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