A Multicenter, Randomized, Open-label, 2-arm, Phase II Study With a Safety lead-in Phase Evaluating the Combination of Encorafenib and Cetuximab Versus Irinotecan/Cetuximab or Infusional 5-fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab in Chinese Patients With BRAF V600E Mutant Metastatic Colorectal Cancer
Latest Information Update: 19 Jun 2024
At a glance
- Drugs Cetuximab (Primary) ; Encorafenib (Primary) ; Fluorouracil (Primary) ; Folinic acid (Primary) ; Irinotecan (Primary)
- Indications Colorectal cancer
- Focus Adverse reactions; Therapeutic Use
- Acronyms NAUTICALCRC
- 15 Jun 2024 Planned End Date changed from 1 Apr 2024 to 11 Jan 2025.
- 04 Jun 2024 Results (n=97; At data cut-off 19 Dec 2023) assessing the safety and efficacy of encorafenib and cetuximab versus irinotecan/cetuximab or FOLFIRI/cetuximab in patients with BRAF V600E mutant metastatic colorectal cancer, presented at the 60th Annual Meeting of the American Society of Clinical Oncology.
- 05 May 2023 Status changed from recruiting to active, no longer recruiting.