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A Randomized, Double-blind, Multicenter, Phase III Study Comparing the Efficacy and Safety of AK104 Plus Oxaliplatin and Capecitabine (XELOX) Versus Placebo Plus XELOX as First-line Treatment for Locally Advanced Unresectable or G/GEJ Adenocarcinoma

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Trial Profile

A Randomized, Double-blind, Multicenter, Phase III Study Comparing the Efficacy and Safety of AK104 Plus Oxaliplatin and Capecitabine (XELOX) Versus Placebo Plus XELOX as First-line Treatment for Locally Advanced Unresectable or G/GEJ Adenocarcinoma

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 21 Nov 2025

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At a glance

  • Drugs Cadonilimab (Primary) ; Capecitabine; Oxaliplatin
  • Indications Adenocarcinoma; Gastric cancer; Oesophageal cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms COMPASSION-15
  • Sponsors Akeso Biopharma

Most Recent Events

  • 19 Nov 2025 Status changed from active, no longer recruiting to completed.
  • 19 Oct 2025 According to Akeso Biopharma media release, data from the trial were presented at the 2025 European Society of Medical Oncology Congress (ESMO 2025) .
  • 19 Oct 2025 Results presented in the Akeso Media Release

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