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A Pivotal Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study of the Efficacy and Safety of DMX-200 in Patients With Focal Segmental Glomerulosclerosis (FSGS) Who Are Receiving an Angiotensin II Receptor Blocker (ARB)

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Trial Profile

A Pivotal Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study of the Efficacy and Safety of DMX-200 in Patients With Focal Segmental Glomerulosclerosis (FSGS) Who Are Receiving an Angiotensin II Receptor Blocker (ARB)

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 25 Dec 2025

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At a glance

  • Drugs Irbesartan/propagermanium (Primary) ; Azilsartan medoxomil; Candesartan cilexetil; Irbesartan; Losartan; Olmesartan medoxomil; Telmisartan; Valsartan
  • Indications Focal segmental glomerulosclerosis
  • Focus Adverse reactions; Registrational; Therapeutic Use
  • Acronyms ACTION3
  • Sponsors Dimerix Bioscience

Most Recent Events

  • 15 Dec 2025 According to a Dimerix media release, recruitment of pediatric patients remains ongoing as an independent cohort in the trial and, if successful, may allow company to expand its application of DMX-200 to adolescents in key territories.
  • 15 Dec 2025 According to a Dimerix media release, the study has successfully passed seven scheduled Independent Data Monitoring Committee (IDMC) reviews, with no protocol changes required and no safety concerns identified.
  • 15 Dec 2025 Status changed to active, no longer recruiting.

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