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A Phase 3 Open-Label, Randomized Study of Pirtobrutinib (LOXO-305) Versus Bendamustine Plus Rituximab in Untreated Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Trial Profile

A Phase 3 Open-Label, Randomized Study of Pirtobrutinib (LOXO-305) Versus Bendamustine Plus Rituximab in Untreated Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 23 Dec 2025

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At a glance

  • Drugs Pirtobrutinib (Primary) ; Bendamustine; Rituximab
  • Indications Chronic lymphocytic leukaemia
  • Focus Registrational; Therapeutic Use
  • Acronyms BRUIN CLL-313
  • Sponsors Loxo Oncology

Most Recent Events

  • 09 Dec 2025 According to American Society of Hematology media release, data from this study were presented at the 67th American Society of Hematology (ASH) Annual Meeting and Exposition.
  • 09 Dec 2025 According to an Eli Lilly and Company media release, data from this trial being presented at at the 67th American Society of Hematology (ASH) Annual Meeting and Exposition taking place in Orlando, Florida and simultaneously published in the Journal of Clinical Oncology.
  • 09 Dec 2025 Results presented at Eli Lilly and Company media release.

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