A Phase 3 Open-Label, Randomized Study of Pirtobrutinib (LOXO-305) Versus Bendamustine Plus Rituximab in Untreated Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Latest Information Update: 04 Feb 2026
At a glance
- Drugs Pirtobrutinib (Primary) ; Bendamustine; Rituximab
- Indications Chronic lymphocytic leukaemia
- Focus Registrational; Therapeutic Use
- Acronyms BRUIN CLL-313
- Sponsors Loxo Oncology
Most Recent Events
- 22 Jan 2026 Planned End Date changed from 1 Aug 2026 to 1 Oct 2027.
- 09 Dec 2025 According to American Society of Hematology media release, data from this study were presented at the 67th American Society of Hematology (ASH) Annual Meeting and Exposition.
- 09 Dec 2025 According to an Eli Lilly and Company media release, data from this trial being presented at at the 67th American Society of Hematology (ASH) Annual Meeting and Exposition taking place in Orlando, Florida and simultaneously published in the Journal of Clinical Oncology.