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A Phase 1/2a, Open-Label, Multicenter, Nonrandomized, Safety and Anti-tumor Activity Study of IMM-1-104, a Novel Oral Dual MEK1/2 Inhibitor in Participants With Previously Treated RAS-Mutated Advanced or Metastatic Solid Tumors

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Trial Profile

A Phase 1/2a, Open-Label, Multicenter, Nonrandomized, Safety and Anti-tumor Activity Study of IMM-1-104, a Novel Oral Dual MEK1/2 Inhibitor in Participants With Previously Treated RAS-Mutated Advanced or Metastatic Solid Tumors

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 20 May 2024

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At a glance

  • Drugs IMM 1 104 (Primary) ; Folinic acid; Gemcitabine; Irinotecan; Oxaliplatin; Paclitaxel
  • Indications Adenocarcinoma; Colon cancer; Colorectal cancer; Ductal carcinoma; Malignant melanoma; Non-small cell lung cancer; Pancreatic cancer; Solid tumours
  • Focus Adverse reactions; Proof of concept; Therapeutic Use
  • Sponsors Immuneering
  • Most Recent Events

    • 07 May 2024 According to an Immuneering Corporation media release, results from the Phase 1 portion of this Phase 1/2a study presented at the American Association for Cancer Research (AACR) Annual Meeting.
    • 14 Mar 2024 According to an Immuneering Corporation media release, company plans to present further data from the ongoing Phase 1 portion of its Phase 1/2a study of IMM-1-104 in advanced RAS-mutant solid tumors at a future medical meeting.
    • 14 Mar 2024 According to an Immuneering Corporation media release, company expect to report initial data from multiple arms of this Phase 2a portion in 2024, and look forward to sharing that data later this year. The Phase 1 portion is being conducted at five clinical sites in the United States. The Phase 2a portion is expected to include up to twenty clinical sites and has already dosed its first patient.
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