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Phase 1/2, Open-label, Dose Escalation and Dose Expansion of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab or Standard of Care Chemotherapy in Participants Aged 18 Years or Older With Locally Advanced or Metastatic Solid Tumor Malignancies

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Trial Profile

Phase 1/2, Open-label, Dose Escalation and Dose Expansion of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab or Standard of Care Chemotherapy in Participants Aged 18 Years or Older With Locally Advanced or Metastatic Solid Tumor Malignancies

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 18 Sep 2024

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At a glance

  • Drugs Onvapegleukin alfa (Primary) ; Pembrolizumab (Primary) ; TransCon TLR7/8 Agonist (Primary) ; Antineoplastics
  • Indications Cervical cancer; Colorectal cancer; Endometrial cancer; Head and neck cancer; Malignant melanoma; Pancreatic cancer; Small cell lung cancer; Solid tumours; Squamous cell cancer
  • Focus Adverse reactions; First in man
  • Acronyms IL Believe
  • Sponsors Ascendis Pharma

    • Most Recent Events

    • 13 Sep 2024 According to Ascendis Pharma media release, Present First Results from Platinum-Resistant Ovarian Cancer (PROC) Cohort of this trial at ESMO 2024.
    • 04 Jun 2024 Updated results (As of 07 Dec 2023; n=46) presented at the 60th Annual Meeting of the American Society of Clinical Oncology.
    • 03 Jun 2024 According to Ascendis Pharma media release, data from this trial presented at the American Society for Clinical Oncology (ASCO)

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