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IL Believe: A Phase 1/2, Open-label, Dose Escalation and Dose Expansion Study to Investigate the Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab, TransCon TLR7/8 Agonist, or Other Anticancer Therapies, in Adult Participants With Locally Advanced or Metastatic Solid Tumor Malignancies

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Trial Profile

IL Believe: A Phase 1/2, Open-label, Dose Escalation and Dose Expansion Study to Investigate the Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab, TransCon TLR7/8 Agonist, or Other Anticancer Therapies, in Adult Participants With Locally Advanced or Metastatic Solid Tumor Malignancies

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 29 Jun 2025

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At a glance

  • Drugs Onvapegleukin alfa (Primary) ; Pembrolizumab (Primary) ; TransCon TLR7/8 Agonist (Primary) ; Docetaxel; Paclitaxel; Pemetrexed
  • Indications Cervical cancer; Colorectal cancer; Endometrial cancer; Head and neck cancer; Malignant melanoma; Pancreatic cancer; Small cell lung cancer; Solid tumours; Squamous cell cancer
  • Focus Adverse reactions; First in man
  • Acronyms IL Believe
  • Sponsors Ascendis Pharma

Most Recent Events

  • 05 Feb 2025 Planned number of patients changed from 393 to 345.
  • 08 Oct 2024 Planned End Date changed from 1 Aug 2027 to 1 Aug 2029.
  • 08 Oct 2024 Planned primary completion date changed from 1 May 2026 to 1 Aug 2027.

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