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A Phase 1/2 Study of Avutometinib (VS-6766) in Combination With Sotorasib With or Without Defactinib in Patients With KRAS G12C Mutant Non-Small Cell Lung Cancer (NSCLC)

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Trial Profile

A Phase 1/2 Study of Avutometinib (VS-6766) in Combination With Sotorasib With or Without Defactinib in Patients With KRAS G12C Mutant Non-Small Cell Lung Cancer (NSCLC)

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 28 Dec 2024

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At a glance

  • Drugs Avutometinib (Primary) ; Defactinib (Primary) ; Sotorasib (Primary)
  • Indications Non-small cell lung cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms RAMP203
  • Sponsors Verastem Oncology
  • Most Recent Events

    • 18 Dec 2024 According to a Verastem Oncology media release, the Company plans to complete enrollment and evaluate the safety and efficacy of the triplet combination, before expanding either of the doublet cohorts.
    • 18 Dec 2024 According to a Verastem Oncology media release, additional enrollment expected and an interim update is planned to be presented at a medical meeting in the second half of 2025.
    • 18 Dec 2024 Results (As of a November 21, 2024) presented in the Verastem Oncology Media Release.

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