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KB407-02 A Phase 1 Study of Inhaled KB407, a Replication-Defective, Non-Integrating Vector Expressing Human Cystic Fibrosis Transmembrane Conductance Regulator, for the Treatment of Cystic Fibrosis

Trial Profile

KB407-02 A Phase 1 Study of Inhaled KB407, a Replication-Defective, Non-Integrating Vector Expressing Human Cystic Fibrosis Transmembrane Conductance Regulator, for the Treatment of Cystic Fibrosis

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 13 May 2025

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At a glance

  • Drugs KB 407 (Primary)
  • Indications Cystic fibrosis
  • Focus Adverse reactions
  • Acronyms CORAL-1
  • Sponsors Krystal Biotech

Most Recent Events

  • 06 May 2025 According to a Krystal Biotech media release, company is on track for an interim molecular data readout for Cohort 3 patients in mid-2025.
  • 19 Feb 2025 According to a Krystal Biotech media release, in January 2025 the Cystic Fibrosis Foundation (CFF) Therapeutic Development Network (TDN) Clinical Research Executive Committee granted full sanctioning of the Company's KB407 Phase 1 CORAL-1 study protocol.
  • 04 Feb 2025 Planned End Date changed from 1 Jul 2024 to 1 Jul 2025.

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