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A 24-week, Multicenter, Randomized, Double Blind, Placebo-controlled, Dose-range Finding Phase II Study to Compare Efficacy and Safety of Oral Masitinib to Placebo in Treatment of Patients With Severe Mast Cell Activation Syndrome (MCAS) With Handicap Unresponsive to Optimal Symptomatic Treatment

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Trial Profile

A 24-week, Multicenter, Randomized, Double Blind, Placebo-controlled, Dose-range Finding Phase II Study to Compare Efficacy and Safety of Oral Masitinib to Placebo in Treatment of Patients With Severe Mast Cell Activation Syndrome (MCAS) With Handicap Unresponsive to Optimal Symptomatic Treatment

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 12 Aug 2026

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At a glance

  • Drugs Masitinib (Primary)
  • Indications Mastocytosis; Systemic mastocytosis
  • Focus Therapeutic Use
  • Sponsors AB Science

Most Recent Events

  • 10 Jul 2026 According to an AB science media release, status changed from recruiting to discontinued to prioritize on other clinical programs in pipeline.
  • 15 Nov 2023 Planned number of patients changed from 72 to 78.
  • 06 Jul 2022 Status changed from planning to recruiting.

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