Trial Profile

A Phase 1/2 Dose-Escalation and Randomized, Controlled, Masked Expansion Trial of Intravitreal 4D-150 Gene Therapy in Adults With Neovascular (Wet) Age-Related Macular Degeneration

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 01 Jul 2025

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At a glance

Drugs 4D-150 (Primary) ; Aflibercept
Indications Wet age-related macular degeneration
Focus Adverse reactions
Acronyms PRISM
Sponsors 4D Molecular Therapeutics

Most Recent Events

25 Jun 2025 Planned End Date changed from 1 Nov 2026 to 1 Jan 2031.
25 Jun 2025 Planned primary completion date changed from 1 Nov 2025 to 1 Mar 2027.
08 Feb 2025 According to a 4D Molecular Therapeutics media release, two-year Phase 1/2a and 18-month Phase 2b PRISM data expected in Q4 2025.

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