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A Phase 1, Open-label, Multi-part Positron Emission Tomography (PET) Imaging Study to Evaluate the Biodistribution and Radiation Dosimetry of the Monoacylglycerol Lipase (MGLL) PET Ligand [18F]T-401 and to Evaluate Fatty Acid Amide Hydrolase (FAAH) and MGLL Enzyme Availability in the Central Nervous System Using [11C]MK-3168 and [18F]T-401 PET Ligands Before and After Oral Administration of Single and Multiple Doses of CC-97489 in Healthy Adult Subjects

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Trial Profile

A Phase 1, Open-label, Multi-part Positron Emission Tomography (PET) Imaging Study to Evaluate the Biodistribution and Radiation Dosimetry of the Monoacylglycerol Lipase (MGLL) PET Ligand [18F]T-401 and to Evaluate Fatty Acid Amide Hydrolase (FAAH) and MGLL Enzyme Availability in the Central Nervous System Using [11C]MK-3168 and [18F]T-401 PET Ligands Before and After Oral Administration of Single and Multiple Doses of CC-97489 in Healthy Adult Subjects

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 21 Feb 2024

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At a glance

  • Drugs CC-97489 (Primary) ; MK 3168 (Primary)
  • Indications Neurological disorders
  • Focus Diagnostic use; Pharmacokinetics
  • Sponsors Celgene Corporation

    • Most Recent Events

    • 15 Feb 2024 Status changed from recruiting to completed.
    • 18 Jan 2024 Planned End Date changed from 15 Oct 2023 to 29 Jan 2024.
    • 18 Jan 2024 Planned primary completion date changed from 15 Oct 2023 to 29 Jan 2024.

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