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A Phase II Multi-Arm (Basket) Trial Investigating the Safety and Efficacy of IO102-IO103 in Combination With Pembrolizumab, as First-Line Treatment for Patients With Metastatic NSCLC, SCCHN, or Metastatic mUBC

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Trial Profile

A Phase II Multi-Arm (Basket) Trial Investigating the Safety and Efficacy of IO102-IO103 in Combination With Pembrolizumab, as First-Line Treatment for Patients With Metastatic NSCLC, SCCHN, or Metastatic mUBC

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 11 Dec 2025

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At a glance

  • Drugs Adjuvanted imsapepimut and etimupepimut (Primary) ; Pembrolizumab (Primary)
  • Indications Adenocarcinoma; Bladder cancer; Carcinoma; Head and neck cancer; Non-small cell lung cancer; Oropharyngeal cancer; Pelvic cancer; Renal cancer; Squamous cell cancer; Ureteral neoplasms; Urethral cancer; Urogenital cancer
  • Focus Therapeutic Use
  • Acronyms Basket trial
  • Sponsors IO Biotech

Most Recent Events

  • 14 Nov 2025 According to an IO Biotech media release, The company presented a poster at ESMO of final data from the Phase 2 basket trial.
  • 23 Sep 2025 According to an IO Biotech media release, company announced that a late-breaking abstract has been accepted and selected as a Proffered Paper oral presentation at the 2025 European Society for Medical Oncology (ESMO) Congress taking place in Berlin, Germany from October 17-21, 2025.
  • 14 Aug 2025 According to an IO Biotech media release, company continues to expect initial data from this trial to be available in the second half of 2025 and presented at a medical meeting in 2026.

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