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ASTEROID:A Phase I Trial of ASTX660 in Combination With Pembrolizumab in Patients With Solid Tumours: Utilizing Triple IAP Blockade as a Strategy to Maximize Immunogenic Cell Death and the Generation of an Efficient Adaptive Immune Response

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ASTEROID:A Phase I Trial of ASTX660 in Combination With Pembrolizumab in Patients With Solid Tumours: Utilizing Triple IAP Blockade as a Strategy to Maximize Immunogenic Cell Death and the Generation of an Efficient Adaptive Immune Response

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 04 Jun 2024

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At a glance

  • Drugs Pembrolizumab (Primary) ; Tolinapant (Primary)
  • Indications Adenocarcinoma; Advanced breast cancer; Cervical cancer; Cholangiocarcinoma; Glioblastoma; Head and neck cancer; Liver cancer; Pancreatic cancer; Solid tumours; Triple negative breast cancer
  • Focus Adverse reactions; Proof of concept; Therapeutic Use
  • Acronyms ASTEROID

    • Most Recent Events

    • 10 Apr 2024 Results (n=22) containing updates on the safety, pharmacodynamic (PD), and clinical activity of 7 days of oral ASTX660 given prior to pembrolizumab in patients refractory to standard therapy, presented at the 115th Annual Meeting of the American Association for Cancer Research.
    • 25 May 2022 Status changed from not yet recruiting to recruiting.
    • 21 Oct 2021 New trial record

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