Trial Profile

A Phase 1/2 Study of ASP1570 as Monotherapy and in Combination With Pembrolizumab and/or Standard Therapies Including Chemotherapy and/or Immunotherapy in Participants With Locally Advanced or Metastatic Solid Tumors

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 12 Mar 2026

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At a glance

Drugs ASP 1570 (Primary) ; Bevacizumab (Primary) ; Docetaxel (Primary) ; Pembrolizumab (Primary)
Indications Colorectal cancer; Malignant melanoma; Non-small cell lung cancer; Solid tumours
Focus Adverse reactions
Sponsors Astellas Pharma Global Development

20 Oct 2025 Planned number of patients changed from 310 to 366.
27 Dec 2024 Protocol amended to exclude one arm; Experimental: ASP1570 Monotherapy Tumor Specific Dose Expansion - Response-triggered Tumor (Part 2)
27 Dec 2024 Planned number of patients changed from 330 to 310.

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