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A two-part open label Phase 1/2 study to investigate the safety, pharmacokinetics, pharmacodynamics and clinical activity of the combination of cetuximab, cobimetinib and palbociclib in subjects with K-RAS wild-type BRAF V600E mutated, or K-RAS mutated, advanced or metastatic colorectal cancer who have failed all available standard therapies

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Trial Profile

A two-part open label Phase 1/2 study to investigate the safety, pharmacokinetics, pharmacodynamics and clinical activity of the combination of cetuximab, cobimetinib and palbociclib in subjects with K-RAS wild-type BRAF V600E mutated, or K-RAS mutated, advanced or metastatic colorectal cancer who have failed all available standard therapies

Status: Not yet recruiting
Phase of Trial: Phase I/II

Latest Information Update: 18 Apr 2022

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At a glance

  • Drugs Cetuximab (Primary) ; Cobimetinib (Primary) ; Palbociclib (Primary)
  • Indications Colorectal cancer
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors Cothera Bioscience

    • Most Recent Events

    • 28 Oct 2021 New trial record

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