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A Phase 3 Randomized, Open-Label Study of Zanubrutinib (BGB-3111) Plus Rituximab Versus Lenalidomide Plus Rituximab in Patients With Relapsed/Refractory Marginal Zone Lymphoma

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Trial Profile

A Phase 3 Randomized, Open-Label Study of Zanubrutinib (BGB-3111) Plus Rituximab Versus Lenalidomide Plus Rituximab in Patients With Relapsed/Refractory Marginal Zone Lymphoma

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 20 Jun 2026

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At a glance

  • Drugs Obinutuzumab (Primary) ; Zanubrutinib (Primary) ; Lenalidomide; Rituximab
  • Indications Follicular lymphoma; Marginal zone B-cell lymphoma
  • Focus Registrational; Therapeutic Use
  • Acronyms MAHOGANY
  • Sponsors BeOne Medicines

Most Recent Events

  • 06 May 2026 According to BeOne Medicines media release, company submitted New Drug Application in Japan for R/R MZL and tablet formulation.
  • 14 Jul 2025 Planned number of patients changed from 864 to 811.
  • 18 Apr 2025 Planned number of patients changed from 750 to 780.

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