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Phase II, Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Safety and Immunogenicity of a Modified Vaccinia Ankara (MVA)-Based Anti-Cytomegalovirus (CMV) Vaccine (Triplex®), in Adults With Both Human Immunodeficiency Virus (HIV)-1 and CMV Who Are on Potent Combination ART With Conserved Immune Function

Trial Profile

Phase II, Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Safety and Immunogenicity of a Modified Vaccinia Ankara (MVA)-Based Anti-Cytomegalovirus (CMV) Vaccine (Triplex®), in Adults With Both Human Immunodeficiency Virus (HIV)-1 and CMV Who Are on Potent Combination ART With Conserved Immune Function

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 28 May 2026

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At a glance

  • Drugs MVA CMV (Primary)
  • Indications HIV-1 infections
  • Focus Adverse reactions; Therapeutic Use

Most Recent Events

  • 14 May 2026 Primary endpoints were amended by removing the endpoint assessing change in pp65-specific CD137+ CD8+ T cells from Day 0 to Week 12. Additionally, detailed descriptions and assessment methodologies were added for the remaining primary endpoints evaluating occurrence of Grade greater and equal 3 adverse events and change in sTNFRII from Day 0 through Week 48.
  • 12 Nov 2025 Status changed from active, no longer recruiting to completed.
  • 18 Jan 2024 Status changed from recruiting to active, no longer recruiting.

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