Phase II, Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Safety and Immunogenicity of a Modified Vaccinia Ankara (MVA)-Based Anti-Cytomegalovirus (CMV) Vaccine (Triplex®), in Adults With Both Human Immunodeficiency Virus (HIV)-1 and CMV Who Are on Potent Combination ART With Conserved Immune Function
Latest Information Update: 28 May 2026
At a glance
- Drugs MVA CMV (Primary)
- Indications HIV-1 infections
- Focus Adverse reactions; Therapeutic Use
Most Recent Events
- 14 May 2026 Primary endpoints were amended by removing the endpoint assessing change in pp65-specific CD137+ CD8+ T cells from Day 0 to Week 12. Additionally, detailed descriptions and assessment methodologies were added for the remaining primary endpoints evaluating occurrence of Grade greater and equal 3 adverse events and change in sTNFRII from Day 0 through Week 48.
- 12 Nov 2025 Status changed from active, no longer recruiting to completed.
- 18 Jan 2024 Status changed from recruiting to active, no longer recruiting.