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A Phase 1/2, Multi-Center, Open-Label Study to Evaluate the Safety, Tolerability, and Preliminary Anti-tumor Activity of TNG908 in Patients With MTAP-deleted Advanced or Metastatic Solid Tumors

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Trial Profile

A Phase 1/2, Multi-Center, Open-Label Study to Evaluate the Safety, Tolerability, and Preliminary Anti-tumor Activity of TNG908 in Patients With MTAP-deleted Advanced or Metastatic Solid Tumors

Status: Discontinued
Phase of Trial: Phase I/II

Latest Information Update: 11 Nov 2024

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At a glance

  • Drugs TNG 908 (Primary)
  • Indications Adenocarcinoma; Cholangiocarcinoma; Glioblastoma; Mesothelioma; Non-small cell lung cancer; Pancreatic cancer; Peripheral nervous system neoplasms; Solid tumours; Squamous cell cancer; Urogenital cancer
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Sponsors Tango Therapeutics

    • Most Recent Events

    • 06 Nov 2024 Status changed from recruiting to discontinued, according to Tango Therapeutics media release. ( TNG908 enrollment is being stopped in order to fully resource TNG462 and TNG456.)
    • 06 Nov 2024 Results presented in a Tango Therapeutics media release.
    • 06 Nov 2024 According to Tango Therapeutics media release, with a data cutoff of 20 October 2024, a total of 103 patients have been enrolled, 70 non-CNS patients across 24 histologies and 33 glioblastoma patients.

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