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Phase I/II Study of CDK4/6 Inhibition With Abemaciclib to Upregulate PSMA Expression Prior to 177Lu-PSMA-617 Treatment in Patients With Metastatic Castrate Resistant Prostate Cancer (mCRPC) Previously Treated With Novel Hormonal Agents and Chemotherapy

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Phase I/II Study of CDK4/6 Inhibition With Abemaciclib to Upregulate PSMA Expression Prior to 177Lu-PSMA-617 Treatment in Patients With Metastatic Castrate Resistant Prostate Cancer (mCRPC) Previously Treated With Novel Hormonal Agents and Chemotherapy

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 31 May 2024

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At a glance

  • Drugs Abemaciclib (Primary) ; Lutetium (177Lu) vipivotide tetraxetan (Primary)
  • Indications Adenocarcinoma; Prostate cancer
  • Focus Adverse reactions; Pharmacokinetics
  • Acronyms UPLIFT

    • Most Recent Events

    • 26 May 2024 Status changed to recruiting.
    • 21 Jun 2023 Status changed from recruiting to active, no longer recruiting.
    • 11 Jul 2022 Planned End Date changed from 31 May 2027 to 31 Jul 2027.

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