A Phase I/II Clinical Trial of "Off-the-shelf" NK Cell Administration in Combination With Allogeneic SCT to Decrease Disease Relapse in Patients With High-risk Myeloid Malignancies Undergoing Matched Related, Matched Unrelated, One Antigen Mismatched Unrelated, or Haploidentical Stem-cell Transplantation
Latest Information Update: 22 Aug 2024
At a glance
- Drugs Cyclophosphamide (Primary) ; Filgrastim (Primary) ; Filgrastim (Primary) ; Fludarabine (Primary) ; Melphalan (Primary) ; Mesna (Primary) ; Mycophenolate mofetil (Primary) ; Mycophenolate mofetil (Primary) ; SAR 445419 (Primary) ; Tacrolimus (Primary) ; Tacrolimus (Primary)
- Indications Acute myeloid leukaemia; Chronic myeloid leukaemia; Graft-versus-host disease; Myelodysplastic syndromes
- Focus Adverse reactions
- 20 Aug 2024 Planned End Date changed from 1 Jun 2024 to 1 Jun 2026.
- 20 Aug 2024 Planned primary completion date changed from 1 Jun 2024 to 1 Jun 2026.
- 13 Dec 2022 Trial design presented at the 64th American Society of Hematology Annual Meeting and Exposition.