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A Randomized, Open-Label, Phase 3 Study to Evaluate Zimberelimab and Domvanalimab in Combination With Chemotherapy Versus Pembrolizumab With Chemotherapy for the First-Line Treatment of Patients With Metastatic Non-Small Cell Lung Cancer With No Epidermal Growth Factor Receptor or Anaplastic Lymphoma Kinase Genomic Tumor Aberrations

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A Randomized, Open-Label, Phase 3 Study to Evaluate Zimberelimab and Domvanalimab in Combination With Chemotherapy Versus Pembrolizumab With Chemotherapy for the First-Line Treatment of Patients With Metastatic Non-Small Cell Lung Cancer With No Epidermal Growth Factor Receptor or Anaplastic Lymphoma Kinase Genomic Tumor Aberrations

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 21 Sep 2024

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At a glance

  • Drugs Domvanalimab (Primary) ; Zimberelimab (Primary) ; Carboplatin; Cisplatin; Paclitaxel; Pembrolizumab; Pemetrexed
  • Indications Non-small cell lung cancer; Squamous cell cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms STAR-121
  • Sponsors Gilead Sciences

    • Most Recent Events

    • 15 Aug 2024 Status changed from recruiting to active, no longer recruiting.
    • 08 May 2024 According to an Arcus Biosciences media release, the company is expecting to complete enrollment by the second half of 2024.
    • 05 Apr 2024 Planned End Date changed from 1 Dec 2027 to 1 Sep 2027.

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