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Phase 1/2 Open Label Dose-escalation and Expansion Trial of NKT2152 an Orally Administered HIF2α Inhibitor to Investigate Safety Pharmacokinetics Pharmacodynamics and Clinical Activity in Patients With Advanced Clear Cell Renal Cell Carcinoma

Trial Profile

Phase 1/2 Open Label Dose-escalation and Expansion Trial of NKT2152 an Orally Administered HIF2α Inhibitor to Investigate Safety Pharmacokinetics Pharmacodynamics and Clinical Activity in Patients With Advanced Clear Cell Renal Cell Carcinoma

Status: Discontinued
Phase of Trial: Phase I/II

Latest Information Update: 17 Nov 2025

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At a glance

  • Drugs NKT 2152 (Primary)
  • Indications Renal cell carcinoma
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Sponsors NiKang Therapeutics

Most Recent Events

  • 12 Nov 2025 Actual primary completion date is 22 August 2025
  • 12 Nov 2025 Status changed from active, no longer recruiting to discontinued as a result of Sponsor portfolio reprioritization.
  • 16 Oct 2024 Status changed from recruiting to active, no longer recruiting.

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