Trial Profile

Pembrolizumab for Locally Advanced, Irresectable, Non-metastatic dMMR Colorectal Cancers. The PUMA Study

Status: Active, no longer recruiting

Phase of Trial: Phase II

Latest Information Update: 08 Jan 2026

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At a glance

Drugs Pembrolizumab (Primary)
Indications Adenocarcinoma; Colon cancer; Rectal cancer
Focus Therapeutic Use
Acronyms PUMA; The PUMA Study

Most Recent Events

09 Dec 2025 Planned End Date changed from 1 Nov 2026 to 1 Jul 2031.
09 Dec 2025 Planned primary completion date changed from 1 Nov 2025 to 1 Jul 2030.
23 Nov 2023 Planned End Date changed from 1 Jun 2024 to 1 Nov 2026.

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