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Phase I Study of Escalating Doses of 90Y-DOTA-Anti-CD25 Monoclonal Antibody Added to the Conditioning Regimen of Fludarabine, Melphalan, and Organ Sparing Total Marrow and Lymphoid Irradiation (TMLI) as Conditioning for Allogeneic Hematopoietic Cell Transplantation in Patients With High-Risk Acute Leukemia or Myelodysplastic Syndrome

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Trial Profile

Phase I Study of Escalating Doses of 90Y-DOTA-Anti-CD25 Monoclonal Antibody Added to the Conditioning Regimen of Fludarabine, Melphalan, and Organ Sparing Total Marrow and Lymphoid Irradiation (TMLI) as Conditioning for Allogeneic Hematopoietic Cell Transplantation in Patients With High-Risk Acute Leukemia or Myelodysplastic Syndrome

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 06 Jan 2025

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At a glance

  • Drugs Basiliximab (Primary) ; Fludarabine (Primary) ; Melphalan (Primary) ; Palifermin (Primary)
  • Indications Acute myeloid leukaemia; Myelodysplastic syndromes; Precursor cell lymphoblastic leukaemia-lymphoma
  • Focus Adverse reactions

    • Most Recent Events

    • 03 Jan 2025 Planned End Date changed from 13 Dec 2024 to 13 Jun 2027.
    • 03 Jan 2025 Planned primary completion date changed from 13 Dec 2024 to 13 Jun 2027.
    • 29 Jan 2024 Planned End Date changed from 29 Feb 2024 to 13 Dec 2024.

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