Trial Profile

A Phase 2/3, Randomized, Open-Label Study of Maintenance GRT-C901/GRT-R902, A Neoantigen Vaccine, in Combination With Immune Checkpoint Blockade for Patients With Metastatic Colorectal Cancer

Status: Active, no longer recruiting

Phase of Trial: Phase II/III

Latest Information Update: 14 Nov 2024

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At a glance

Drugs Atezolizumab (Primary) ; Bevacizumab (Primary) ; Fluoropyrimidine derivatives (Primary) ; GRANITE 001 (Primary) ; Ipilimumab (Primary) ; Oxaliplatin (Primary)
Indications Colorectal cancer
Focus Registrational; Therapeutic Use
Acronyms GRANITE-CRC-1L
Sponsors Gritstone bio

11 Nov 2024 According to a Gritstone bio media release, overall survival data remain immature, with mature data expected in 2H 2025
11 Nov 2024 Updated Phase 2 Interim results presented in the Gritstone bio Media Release.
30 Sep 2024 According to a Gritstone bio media release, company announced Interim Phase 2 Data for GRANITE Individualized Neoantigen Targeting Immunotherapy in Frontline Metastatic Microsatellite Stable Colorectal Cancer

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