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A phase IA/B open-label study to evaluate safety, pharmacokinetics, and preliminary clinical activity of RO7276389 alone and in combination with cobimetinib in participants with Braf-V600 mutation-positive advanced solid tumor or Braf-V600 mutation-positive melanoma with central nervous system metastases

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Trial Profile

A phase IA/B open-label study to evaluate safety, pharmacokinetics, and preliminary clinical activity of RO7276389 alone and in combination with cobimetinib in participants with Braf-V600 mutation-positive advanced solid tumor or Braf-V600 mutation-positive melanoma with central nervous system metastases

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 16 Jun 2025

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At a glance

  • Drugs Cobimetinib (Primary) ; RG 6344 (Primary)
  • Indications Brain metastases; Malignant melanoma; Solid tumours
  • Focus Adverse reactions
  • Sponsors Roche

Most Recent Events

  • 30 Apr 2025 Results (n=66) presented at the 116th Annual Meeting of the American Association for Cancer Research.
  • 10 May 2023 Planned End Date changed from 15 Mar 2024 to 24 Mar 2025.
  • 09 Dec 2021 Status changed from not yet recruiting to recruiting.

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