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A Phase 1 First-Time-in-Human, Open-Label Study of GSK4381562 Administered as Monotherapy and in Combination With Anticancer Agents in Participants With Selected Advanced Solid Tumors

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Trial Profile

A Phase 1 First-Time-in-Human, Open-Label Study of GSK4381562 Administered as Monotherapy and in Combination With Anticancer Agents in Participants With Selected Advanced Solid Tumors

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 30 Mar 2026

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At a glance

  • Drugs Belrestotug (Primary) ; Dostarlimab (Primary) ; Nelistotug (Primary) ; Remzistotug (Primary) ; Risvutatug rezetecan (Primary)
  • Indications Advanced breast cancer; Carcinoma; Colorectal cancer; Endometrial cancer; Gastric cancer; Head and neck cancer; Non-small cell lung cancer; Ovarian cancer; Renal cell carcinoma; Solid tumours
  • Focus Adverse reactions; First in man
  • Sponsors GlaxoSmithKline; GSK; Surface Oncology

Most Recent Events

  • 23 Mar 2026 Status changed from recruiting to active, no longer recruiting.
  • 23 Mar 2026 Status changed from recruiting to active, no longer recruiting.
  • 20 Feb 2026 This trial has been completed in France.

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