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A Phase 1 and Pharmacokinetic Study of Uproleselan (GMI-1271, NSC #801708) in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome or Mixed Phenotype Acute Leukemia That Expresses E-selectin Ligand on the Cell Membrane and is in Second or Greater Relapse or That is Refractory to Relapse Therapy

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Trial Profile

A Phase 1 and Pharmacokinetic Study of Uproleselan (GMI-1271, NSC #801708) in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome or Mixed Phenotype Acute Leukemia That Expresses E-selectin Ligand on the Cell Membrane and is in Second or Greater Relapse or That is Refractory to Relapse Therapy

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 04 Oct 2024

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At a glance

  • Drugs Cytarabine (Primary) ; Cytarabine (Primary) ; Fludarabine (Primary) ; Uproleselan (Primary) ; Folinic acid; Folinic acid
  • Indications Acute biphenotypic leukaemia; Acute myeloid leukaemia; Myelodysplastic syndromes
  • Focus Adverse reactions; Pharmacokinetics

    • Most Recent Events

    • 25 Sep 2024 Planned End Date changed from 31 Dec 2024 to 31 Dec 2026.
    • 25 Sep 2024 Planned primary completion date changed from 31 Dec 2024 to 31 Dec 2026.
    • 29 Aug 2024 Planned number of patients changed from 18 to 22.

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