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A Randomized, Double-blind, Double-dummy, Parallel-group Study, Comparing the Efficacy and Safety of Remibrutinib Versus Teriflunomide in Participants With Relapsing Multiple Sclerosis, Followed by Extended Treatment With Open-label Remibrutinib

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A Randomized, Double-blind, Double-dummy, Parallel-group Study, Comparing the Efficacy and Safety of Remibrutinib Versus Teriflunomide in Participants With Relapsing Multiple Sclerosis, Followed by Extended Treatment With Open-label Remibrutinib

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 22 Jul 2024

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At a glance

  • Drugs Remibrutinib (Primary) ; Charcoal; Colestyramine; Teriflunomide
  • Indications Multiple sclerosis
  • Focus Registrational; Therapeutic Use
  • Acronyms REMODEL-1
  • Sponsors Novartis Pharma A.G.; Novartis Pharmaceuticals

    • Most Recent Events

    • 13 Jan 2023 Planned End Date changed from 23 Nov 2029 to 30 Oct 2030.
    • 13 Jan 2023 Planned primary completion date changed from 31 Oct 2025 to 30 Apr 2026.
    • 28 Jun 2022 Results from two studies (REMODEL I/II) assessing efficacy, safety, and tolerability of remibrutinib versus teriflunomide in patients with relapsing multiple sclerosis presented at the 8th Congress of the European Academy of Neurology
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