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A Study to Evaluate the Safety and Tolerability of the Covalent Phosphoinositide-3-Kinase (PI3K)-Alpha Inhibitor, TOS-358, in Adult Subjects With Select Solid Tumors

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Trial Profile

A Study to Evaluate the Safety and Tolerability of the Covalent Phosphoinositide-3-Kinase (PI3K)-Alpha Inhibitor, TOS-358, in Adult Subjects With Select Solid Tumors

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 21 May 2026

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At a glance

  • Drugs TOS-358 (Primary)
  • Indications Advanced breast cancer; Cervical cancer; Colorectal cancer; Endometrial cancer; Gastric cancer; Head and neck cancer; HER2 negative breast cancer; Non-small cell lung cancer; Ovarian cancer; Solid tumours; Squamous cell cancer; Urogenital cancer
  • Focus Adverse reactions; First in man
  • Sponsors Totus Medicines

Most Recent Events

  • 07 May 2026 According to a Totus Medicines media release data from this study were presented at the European Society for Medical Oncology (ESMO) Breast Cancer Annual Congress, taking place in Berlin, Germany, May 5 to 8, 2026.
  • 07 May 2026 Results presented in the Totus Medicines media release.
  • 30 Apr 2026 According to a Totus Medicines media release, interim data from this study will be presented at the European Society for Medical Oncology (ESMO) Breast Cancer Annual Congress, taking place in Berlin, Germany, May 5-8, 2026.

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