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A Randomized Phase III Trial of Patients With Advanced Hematologic Malignancies Undergoing Allogeneic Hematopoietic Cell Transplantation With Either Orca-T, a T-cell-Depleted Graft With Additional Infusion of Conventional T Cells and Regulatory T Cells, or Standard-of-Care Allogeneic Graft

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Trial Profile

A Randomized Phase III Trial of Patients With Advanced Hematologic Malignancies Undergoing Allogeneic Hematopoietic Cell Transplantation With Either Orca-T, a T-cell-Depleted Graft With Additional Infusion of Conventional T Cells and Regulatory T Cells, or Standard-of-Care Allogeneic Graft

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 16 Dec 2025

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At a glance

  • Drugs Orca-T (Primary) ; Methotrexate; Tacrolimus
  • Indications Acute biphenotypic leukaemia; Acute myeloid leukaemia; Haematological malignancies; Myelodysplastic syndromes; Precursor cell lymphoblastic leukaemia-lymphoma
  • Focus Registrational; Therapeutic Use
  • Acronyms Orca-T; Precision-T
  • Sponsors Orca Bio

Most Recent Events

  • 06 Dec 2025 According Orca Bio media release, data from this study presented at the 67th American Society of Hematology (ASH) Annual Meeting.
  • 06 Dec 2025 Results published in the Media Release
  • 03 Nov 2025 According Orca Bio media release, the datta from the trial will be presented at the American Society of Hematology (ASH) Annual Meeting.

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