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The purpose of this Phase III study is to evaluate the efficacy and safety of tozorakimab Dose 1 and Dose 2 administered subcutaneously (SC) in adult participants with symptomatic COPD and history of ≥ 2 moderate or ≥ 1 severe exacerbation of COPD in the previous 12 months. Participants should be receiving optimised treatment with maintenance inhaled therapy (ICS/LABA/LAMA triple therapy, or dual therapy if triple is not considered appropriate) in stable doses throughout at least 3 months prior to enrolment

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Trial Profile

The purpose of this Phase III study is to evaluate the efficacy and safety of tozorakimab Dose 1 and Dose 2 administered subcutaneously (SC) in adult participants with symptomatic COPD and history of ≥ 2 moderate or ≥ 1 severe exacerbation of COPD in the previous 12 months. Participants should be receiving optimised treatment with maintenance inhaled therapy (ICS/LABA/LAMA triple therapy, or dual therapy if triple is not considered appropriate) in stable doses throughout at least 3 months prior to enrolment

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 02 Aug 2024

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At a glance

  • Drugs Tozorakimab (Primary)
  • Indications Chronic obstructive pulmonary disease
  • Focus Registrational; Therapeutic Use
  • Acronyms TITANIA
  • Sponsors AstraZeneca

    • Most Recent Events

    • 31 Jul 2024 Planned End Date changed from 28 Aug 2025 to 1 May 2026.
    • 31 Jul 2024 Planned primary completion date changed from 5 Jun 2025 to 2 Feb 2026.
    • 04 Oct 2023 Planned number of patients changed from 1060 to 1272.

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