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A Phase 1 Study to Assess the Safety and Efficacy of LYL797, ROR1-Targeting CAR T Cells, in Adults With Relapsed and/or Refractory Solid-Tumor Malignancies

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Trial Profile

A Phase 1 Study to Assess the Safety and Efficacy of LYL797, ROR1-Targeting CAR T Cells, in Adults With Relapsed and/or Refractory Solid-Tumor Malignancies

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 08 Nov 2024

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At a glance

  • Drugs LYL 797 (Primary) ; Cyclophosphamide; Fludarabine
  • Indications Advanced breast cancer; Chronic lymphocytic leukaemia; Endometrial cancer; Multiple myeloma; Non-small cell lung cancer; Ovarian cancer; Triple negative breast cancer
  • Focus Adverse reactions; First in man
  • Sponsors Lyell Immunopharma

    • Most Recent Events

    • 05 Nov 2024 Status changed from recruiting to active, no longer recruiting.
    • 04 Oct 2024 According to a Lyell Immunopharma media release, translational data from the LYL797 Phase 1 clinical trial will be presented at the 39th Annual Meeting of the Society for Immunotherapy of Cancer (SITC) taking place in Houston, TX on Friday, Nov. 8, 2024.
    • 30 Aug 2024 Planned number of patients changed from 54 to 100.

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