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A Phase 1 Study to Assess the Safety and Efficacy of LYL797, ROR1-Targeting CAR T Cells, in Adults With Relapsed and/or Refractory Solid-Tumor Malignancies

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Trial Profile

A Phase 1 Study to Assess the Safety and Efficacy of LYL797, ROR1-Targeting CAR T Cells, in Adults With Relapsed and/or Refractory Solid-Tumor Malignancies

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 04 Sep 2024

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At a glance

  • Drugs LYL 797 (Primary) ; Cyclophosphamide; Fludarabine
  • Indications Advanced breast cancer; Chronic lymphocytic leukaemia; Endometrial cancer; Multiple myeloma; Non-small cell lung cancer; Ovarian cancer; Triple negative breast cancer
  • Focus Adverse reactions; First in man
  • Sponsors Lyell Immunopharma

    • Most Recent Events

    • 30 Aug 2024 Planned number of patients changed from 54 to 100.
    • 30 Aug 2024 Planned End Date changed from 1 Sep 2026 to 1 Dec 2026.
    • 30 Aug 2024 Planned primary completion date changed from 1 Mar 2025 to 1 Dec 2025.

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