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A Phase 1a/1b, Open-label, Multicenter Trial Investigating the Safety, Tolerability, and Preliminary Anti-neoplastic Activity of S095029 (Anti-NKG2A) as Monotherapy and in Combination With Sym021 (Anti-PD-1) in Patients With Advanced Solid Tumor Malignancies Followed by an Expansion Part With Triplet Combinations of S095029 and Sym021 and an Anti-HER2 mAb or Anti-EGFR mAbs (Futuximab/Modotuximab) in Patients With Metastatic Gastric or Colorectal Cancers

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Trial Profile

A Phase 1a/1b, Open-label, Multicenter Trial Investigating the Safety, Tolerability, and Preliminary Anti-neoplastic Activity of S095029 (Anti-NKG2A) as Monotherapy and in Combination With Sym021 (Anti-PD-1) in Patients With Advanced Solid Tumor Malignancies Followed by an Expansion Part With Triplet Combinations of S095029 and Sym021 and an Anti-HER2 mAb or Anti-EGFR mAbs (Futuximab/Modotuximab) in Patients With Metastatic Gastric or Colorectal Cancers

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 12 Mar 2025

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At a glance

  • Drugs Futuximab/modotuximab (Primary) ; S 095029 (Primary) ; Sym 021 (Primary)
  • Indications Adenocarcinoma; Cancer; Colorectal cancer; Gastric cancer; Solid tumours
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors Servier

Most Recent Events

  • 11 Dec 2024 Planned End Date changed from 20 Jan 2025 to 19 Jun 2025.
  • 02 Aug 2024 Planned End Date changed from 31 Jul 2024 to 20 Jan 2025.
  • 08 Apr 2024 Planned End Date changed from 1 Feb 2024 to 31 Jul 2024.

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